Researchers from Humboldt University, Berlin, administered THC, a synthetic form of THC, ethanol, an anticonvulsant called MK-801, and phenobarbital to rats between one and 14 days old. A previous study by the same team found that ethanol and drugs such as sedatives, anesthetics and anticonvulsants caused extensive nerve cell death in the brains of young rodents. The new study was conducted to determine if cannabinoids caused similar harm.The researchers found that THC and synthetic THC did not cause nerve cell death when administered alone but did cause cell death when given with mildly intoxicating amounts of ethanol. The combined effect increased according to the dose of THC and was strongest when the rats were seven days old.
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