24 jan. 2009

Apoptosis Inhibitors Prevent Not Only Cell Death, But Also Play A Role In Cell Migration

One of the defining characteristics of cancer cells is that they systematically prevent programmed cell death (apoptosis), with which the body guards itself against the proliferation of defective cells. In order to do this, they express so-called apoptosis inhibitors (IAPs) among other proteins. Many of the cancer drugs currently undergoing clinical trials target IAPs, since if the levels of IAPs are reduced, tumour cells will be destroyed by the body's own self-protecting mechanism or by the chemotherapeutic drugs. However, as a research group from the Goethe University in Frankfurt, working with scientists at the Universities of Würzburg and Philadelphia have recently discovered, IAPs also have another life: they control cell migration.

________________________________________________